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The most abundant miRNA in the samples was the miR-125a-3p, which has been shown to inactivate the Wnt/β-catenin and NF-κB pathways, and also that its downregulation correlates with tumorigenesis 70,71 —this particular miRNA’s load in the EVs was reduced with Cytochalasin D treatment, and increased with R5421 (Fig
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